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KMID : 0358419960390071325
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Korean Journal of Obstetrics and Gynecology
1996 Volume.39 No. 7 p.1325 ~ p.1330
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Intracytoplasmic Sperm Injection using Epididymal and Testicular Spermatozoa
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손일표
이유식/서주태/전진현/박용석/이호준/강인수/전종영
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Abstract
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In cases requiring microsurgical epididymal sperm aspiration(MESA) for congenital absence of the vas deferens(CAVD) or unreconstructable obstructive azoospermia, often no spermatozoa can be retrieved from epididymis, or there may even be no
epididymis
present. We wished to see whether testicular biopsy with testicular sperm extraction(TESE) in such cases could yield spermatozoa that would result in successful fertilization and pregnancy using intracytoplasmic sperm injection(ICSI). 179 cycles
with
CAVD or unreconstructable obstructive azoospermia were treated ; 91 MESA-ICSI cycles and 88 TESE-ICSI cycles were performed. Normal two-pronuclear fertilization rates were similar in both groups : 69.5% for MESA-ICSI group and 76.0% for TESE-ICSI
group.
The pregnancy rates in this series were 44.0% and 36.4% respectively. The clinical pregnancy rates were 35.2% and 34.1%. We concluded that epididymal spermatozoa and testicular spermatozoa yield similar fertilization and pregnancy rates using
ICSI.
When
epididymal spermatozoa cannot be retrieved, a testicular biopsy can be performed and the few barely motile spermatoza thus obtained can be used for ICSI. It appears that all cases of obstructive azoospermia can be now be successfully treated.
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